Tumour necrosis factor alpha, ınterleukin 10 and ınterleukin 6 gene polymorphisms of ıschemic stroke patients ın south Marmara region of Turkey.

Autor: Ozkan A; Department of Neurology, Canakkale 18 Mart University Medical Faculty Canakkale, Turkey., Sılan F; Department of Genetics, Canakkale 18 Mart University Medical Faculty Canakkale, Turkey., Uludağ A; Department of Genetics, Canakkale 18 Mart University Medical Faculty Canakkale, Turkey., Degirmenci Y; Department of Neurology, Duzce University Medical Faculty Duzce, Turkey., Ozisik Karaman HI; Department of Neurology, Canakkale 18 Mart University Medical Faculty Canakkale, Turkey.
Jazyk: angličtina
Zdroj: International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2015 Oct 01; Vol. 8 (10), pp. 13500-4. Date of Electronic Publication: 2015 Oct 01 (Print Publication: 2015).
Abstrakt: Background: Stroke is an important cause of adult mortality and morbidity; however its pathogenesis is still unknown. Several studies have examined to determine the role of genetic polymorphism of proinflammatory cytokines in the occurence of stroke. The objective of this study was to evaluate the relationship between three polymorphisms; including tumour necrosis alpha (TNFα)-238 GA, interleukin( IL-10)-1028 GA (rs1800896), IL-6-(rs1800795) and ischemic stroke in a Turkish population.
Methods: Forty two stroke patients and 48 healhty controls were genotyped using PCR analysis for TNFα-238 G/A, IL-10-1028 GA and IL-6-rs1800795 AG polymorphisms.
Results: The frequency of the CC and CG, GG genotype of IL-6 gene (rs1800795) were statiscially significiantly higher in IS patients than controls (for C/C genotype, P=0.03, OR=4.3; 95% CI: 1.13 to 16.29 and for C/G genotype, P=0.04, OR=3.6; 95% CI: 1.03 to 12.95, for G/G genotype, P=0.02, OR=0.25; 95% CI: 0.07-0.85 respectively).
Conclusion: Il-6 CC genotyped was found strongly associated with ischemic stroke than other two polymorpisms TNF-α and IL-10 in our population.
Databáze: MEDLINE
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