The complex role of SIRT6 in carcinogenesis.
| Autor: | Lerrer B; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel., Gertler AA; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel., Cohen HY; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel Haim.Cohen@biu.ac.il. |
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| Jazyk: | angličtina |
| Zdroj: | Carcinogenesis [Carcinogenesis] 2016 Feb; Vol. 37 (2), pp. 108-18. Date of Electronic Publication: 2015 Dec 30. |
| DOI: | 10.1093/carcin/bgv167 |
| Abstrakt: | SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD(+)-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan. (© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
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