Anhedonia and cognitive function in adults with MDD: results from the International Mood Disorders Collaborative Project.

Autor:	McIntyre RS; 1Department of Psychiatry,University of Toronto,Toronto,Ontario,Canada., Woldeyohannes HO; 3Mood Disorders Psychopharmacology Unit,University Health Network,Toronto,Ontario,Canada., Soczynska JK; 3Mood Disorders Psychopharmacology Unit,University Health Network,Toronto,Ontario,Canada., Maruschak NA; 3Mood Disorders Psychopharmacology Unit,University Health Network,Toronto,Ontario,Canada., Wium-Andersen IK; 5Department of Psychiatry,Psychiatric Center,Copenhagen,Denmark., Vinberg M; 5Department of Psychiatry,Psychiatric Center,Copenhagen,Denmark., Cha DS; 3Mood Disorders Psychopharmacology Unit,University Health Network,Toronto,Ontario,Canada., Lee Y; 3Mood Disorders Psychopharmacology Unit,University Health Network,Toronto,Ontario,Canada., Xiao HX; 3Mood Disorders Psychopharmacology Unit,University Health Network,Toronto,Ontario,Canada., Gallaugher LA; 3Mood Disorders Psychopharmacology Unit,University Health Network,Toronto,Ontario,Canada., Dale RM; 6Cleveland Clinic,Cleveland,Ohio,USA., Alsuwaidan MT; 3Mood Disorders Psychopharmacology Unit,University Health Network,Toronto,Ontario,Canada., Mansur RB; 3Mood Disorders Psychopharmacology Unit,University Health Network,Toronto,Ontario,Canada., Muzina DJ; 7Turn2Health Solutions,Willoughby,Ohio,USA., Carvalho AF; 8Translational Psychiatry Research Group and Department of Clinical Medicine, Faculty of Medicine,Federal University of Ceara,Fortaleza,Brazil., Jerrell JM; 9Department of Neuropsychiatry,University of South Carolina School of Medicine,Columbia,South Carolina,USA., Kennedy SH; 1Department of Psychiatry,University of Toronto,Toronto,Ontario,Canada.
Jazyk:	angličtina
Zdroj:	CNS spectrums [CNS Spectr] 2016 Oct; Vol. 21 (5), pp. 362-366. Date of Electronic Publication: 2015 Dec 30.
DOI:	10.1017/S1092852915000747
Abstrakt:	Background: Cognitive dysfunction is common in major depressive disorder (MDD) and a critical determinant of health outcome. Anhedonia is a criterion item toward the diagnosis of a major depressive episode (MDE) and a well-characterized domain in MDD. We sought to determine the extent to which variability in self-reported cognitive function correlates with anhedonia. Method: A post hoc analysis was conducted using data from (N=369) participants with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR)-defined diagnosis of MDD who were enrolled in the International Mood Disorders Collaborative Project (IMDCP) between January 2008 and July 2013. The IMDCP is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Toronto, Canada, and the Cleveland Clinic, Cleveland, Ohio. Measures of cognitive function, anhedonia, and depression severity were analyzed using linear regression equations. Results: A total of 369 adults with DSM-IV-TR-defined MDD were included in this analysis. Self-rated cognitive impairment [ie, as measured by the Adult ADHD Self-Report Scale (ASRS)] was significantly correlated with a proxy measure of anhedonia (r=0.131, p=0.012). Moreover, total depression symptom severity, as measured by the total Montgomery-Åsberg Depression Rating Scale (MADRS) score, was also significantly correlated with self-rated measures of cognitive dysfunction (r=0.147, p=0.005). The association between anhedonia and self-rated cognitive dysfunction remained significant after adjusting for illness severity (r=0.162, p=0.007). Conclusions: These preliminary results provide empirical data for the testable hypothesis that anhedonia and self-reported cognitive function in MDD are correlated yet dissociable domains. The foregoing observation supports the hypothesis of overlapping yet discrete neurobiological substrates for these domains.
Databáze:	MEDLINE
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