Atheroprotective Properties of Serum IGF-1 in the Carotid and Coronary Territories and Beneficial Role on the Physical Fitness of the Oldest Old.

Autor:	Córdova C; Gerontology Program and Physical Education Program, Catholic University of Brasília (UCB-DF), DF, Brazil., Boullosa DA; Physical Education Program, Catholic University of Brasília (UCB-DF), DF, Brazil., Custódio MR; Physical Education Program, Catholic University of Brasília (UCB-DF), DF, Brazil., Quaglia LA; Medical Faculty, State University of Campinas (UNICAMP), São Paulo, Brazil., Santos SN; Medical Faculty, Universidade de Brasília (UnB), Federal District, Brazil., Freitas WM; Medical Faculty, State University of Campinas (UNICAMP), São Paulo, Brazil., Sposito AC; Medical Faculty, State University of Campinas (UNICAMP), São Paulo, Brazil., Nóbrega OT; Medical Faculty, Universidade de Brasília (UnB), Federal District, Brazil. nobrega@pq.cnpq.br.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2016 Oct; Vol. 71 (10), pp. 1281-8. Date of Electronic Publication: 2015 Dec 28.
DOI:	10.1093/gerona/glv216
Abstrakt:	Our aim was to investigate whether physiological levels of soluble insulin-like growth factor-1 (IGF-1) associate with coronary and carotid atherosclerotic burden and physical fitness in the oldest old by means of a cross-sectional study including 100 community-dwelling individuals with no previous cardiovascular events. Linear correlation was found between IGF-1 and intima-media thickness, number of carotid plaques, and walking speed. Individuals in the upper IGF-1 tertile had smaller right and left intima-media thickness compared with the intermediate and lower tertiles, along with reduced atherosclerotic plaques. Also, walking speed was greater in the upper IGF-1 tertile. On the other hand, a nonlinear correlation was observed between IGF-1 and coronary calcification scores, with the intermediate IGF-1 tertile associated to the lowest scores of calcification and participants with lower circulating levels of IGF-1 showing higher frequency of high-risk morphology plaques. All in all, our report supports a territory-dependent, atherorefractory phenotype in the oldest old carrying middle and/or higher serum levels of IGF-1. (© The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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