Autor: |
Obata A; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Kubota N; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Kubota T; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Iwamoto M; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Sato H; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Sakurai Y; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Takamoto I; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Katsuyama H; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Suzuki Y; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Fukazawa M; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Ikeda S; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Iwayama K; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Tokuyama K; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Ueki K; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan. |