| Autor: |
Emed LG; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.; b Hospital Cardiologico Costantini , Curitiba , PR , Brazil., Passaglia DG; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil., Guerios ST; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil., João PG; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil., Moser AI; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil., Abdalla DS; c Faculdade de Ciências Farmacêuticas , Universidade de São Paulo , São Paulo , Brazil., Guarita-Souza LC; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.; b Hospital Cardiologico Costantini , Curitiba , PR , Brazil., Mikilita ES; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil., Baena CP; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil., da Costa AB; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil., Faria-Neto JR; a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil. |
| Abstrakt: |
We aimed to evaluate the effects of a 24-h ultramarathon, an aerobic test of high physical load, on lipid profile and apolipoproteins B (ApoB) and A1 (ApoA1) levels, minimally modified low-density lipoprotein (LDL), and oxidised LDL. Prospective evaluation of 16 male athletes who participated in an ultramarathon run, where the objective was to run the greatest distance possible in 24 h. Fourteen participants completed the run. The mean distance achieved was 133.1 km (maximum of 169.6 km). There was a trend in reduction of triglycerides and total cholesterol (P = 0.06 and 0.05, respectively), without significant modifications in high-density lipoprotein, LDL and ApoA1 levels (P = 0.16; 0.55 and 0.67). There was a marked reduction in ApoB levels (P < 0.001), correlated directly to the distance covered (Pearson R = 0.68). Accordingly, an increase in the LDL/ApoB ratio was observed. The stress of this physical activity was not associated to an increase in minimally modified LDL or oxidised LDL. Lipid profile levels were not acutely altered by prolonged physical activity. Similarly, there was no evidence of greater oxidation of LDL over a 24-h period of physical activity. The reduction in ApoB was directly proportional to the distance covered, suggesting an acute positive change in phenotype of LDL molecules. |
