Magnetically triggered nanovehicles for controlled drug release as a colorectal cancer therapy.

Autor: Kuo CY; Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan., Liu TY; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan. Electronic address: tyliu0322@gmail.com., Chan TY; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan., Tsai SC; Institute of Microbiology and Immunology, School of Life Science, Nation Yang-Ming University, Taipei 11221, Taiwan., Hardiansyah A; Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan., Huang LY; Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan., Yang MC; Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan., Lu RH; Department of Surgery, Taipei City Hospital, Zhongxing Branch, Taipei 10341, Taiwan., Jiang JK; Department of Surgery, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11221, Taiwan., Yang CY; Department of Education and Research, Taipei City Hospital, Taipei 10629, Taiwan., Lin CH; Institute of Microbiology and Immunology, School of Life Science, Nation Yang-Ming University, Taipei 11221, Taiwan; Department of Surgery, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan., Chiu WY; Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan; Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan; Department of Materials Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2016 Apr 01; Vol. 140, pp. 567-573. Date of Electronic Publication: 2015 Nov 18.
DOI: 10.1016/j.colsurfb.2015.11.008
Abstrakt: Magnetic silica core/shell nanovehicles presenting atherosclerotic plaque-specific peptide-1 (AP-1) as a targeting ligand (MPVA-AP1 nanovehicles) have been prepared through a double-emulsion method and surface modification. Amphiphilic poly(vinyl alcohol) was introduced as a polymer binder to encapsulate various drug molecules (hydrophobic, hydrophilic, polymeric) and magnetic iron oxide (Fe3O4) nanoparticles. Under a high-frequency magnetic field, magnetic carriers (diameter: ca. 50 nm) incorporating the anti-cancer drug doxorubicin collapsed, releasing approximately 80% of the drug payload, due to the heat generated by the rapidly rotating Fe3O4 nanoparticles, thereby realizing rapid and accurate controlled drug release. Simultaneously, the magnetic Fe3O4 themselves could also kill the tumor cells through a hyperthermia effect (inductive heating). Unlike their ungrafted congeners (MPVA nanovehicles), the AP1-grafted nanovehicles bound efficiently to colorectal cancer cells (CT26-IL4Rα), thereby displaying tumor-cell selectivity. The combination of remote control, targeted dosing, drug-loading flexibility, and thermotherapy and chemotherapy suggests that magnetic nanovehicles such as MPVA-AP1 have great potential for application in cancer therapy.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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