Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation.
| Autor: | Harteveld AA; From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.) a.a.harteveld-2@umcutrecht.nl., Denswil NP; Department of Pathology (N.P.D., M.J.D.), Academic Medical Center, Amsterdam, the Netherlands., Siero JC; From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)., Zwanenburg JJ; From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.) Image Sciences Institute (J.J.M.Z.), University Medical Center Utrecht, Utrecht, the Netherlands., Vink A; Pathology (A.V., W.G.M.S.)., Pouran B; Orthopedics (B.P.) Rheumatology (B.P.) Department of Biomedical Engineering (B.P.), Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology, Delft, the Netherlands., Spliet WG; Pathology (A.V., W.G.M.S.)., Klomp DW; From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)., Luijten PR; From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)., Daemen MJ; Department of Pathology (N.P.D., M.J.D.), Academic Medical Center, Amsterdam, the Netherlands., Hendrikse J; From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)., van der Kolk AG; From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.). |
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| Jazyk: | angličtina |
| Zdroj: | AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2016 May; Vol. 37 (5), pp. 802-10. Date of Electronic Publication: 2015 Dec 24. |
| DOI: | 10.3174/ajnr.A4628 |
| Abstrakt: | Background and Purpose: In recent years, several high-resolution vessel wall MR imaging techniques have emerged for the characterization of intracranial atherosclerotic vessel wall lesions in vivo. However, a thorough validation of MR imaging results of intracranial plaques with histopathology is still lacking. The aim of this study was to characterize atherosclerotic plaque components in a quantitative manner by obtaining the MR signal characteristics (T1, T2, T2*, and proton density) at 7T in ex vivo circle of Willis specimens and using histopathology for validation. Materials and Methods: A multiparametric ultra-high-resolution quantitative MR imaging protocol was performed at 7T to identify the MR signal characteristics of different intracranial atherosclerotic plaque components, and using histopathology for validation. In total, 38 advanced plaques were matched between MR imaging and histology, and ROI analysis was performed on the identified tissue components. Results: Mean T1, T2, and T2* relaxation times and proton density values were significantly different between different tissue components. The quantitative T1 map showed the most differences among individual tissue components of intracranial plaques with significant differences in T1 values between lipid accumulation (T1 = 838 ± 167 ms), fibrous tissue (T1 = 583 ± 161 ms), fibrous cap (T1 = 481 ± 98 ms), calcifications (T1 = 314 ± 39 ms), and the intracranial arterial vessel wall (T1 = 436 ± 122 ms). Conclusions: Different tissue components of advanced intracranial plaques have distinguishable imaging characteristics with ultra-high-resolution quantitative MR imaging at 7T. Based on this study, the most promising method for distinguishing intracranial plaque components is T1-weighted imaging. (© 2016 by American Journal of Neuroradiology.) |
| Databáze: | MEDLINE |
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