Drug delivery to macrophages: Challenges and opportunities.

Autor: Pei Y; Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States., Yeo Y; Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, United States. Electronic address: yyeo@purdue.edu.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2016 Oct 28; Vol. 240, pp. 202-211. Date of Electronic Publication: 2015 Dec 11.
DOI: 10.1016/j.jconrel.2015.12.014
Abstrakt: Macrophages are prevalent in the body and have roles in almost every aspect of human biology. They have often been considered a subject to avoid during drug delivery. However, with recent understanding of their diverse functions in diseases, macrophages have gained increasing interest as important therapeutic targets. To develop drug carriers to macrophages, it is important to understand their biological roles and requirements for efficient targeting. This review provides an overview of representative carriers and various approaches to address challenges in drug delivery to macrophages such as biodistribution, cellular uptake, intracellular trafficking, and drug release.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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