Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: a review of 971 cases.

Autor: Perry AM; Department of Pathology, University of Manitoba, Winnipeg, MB, Canada., Diebold J; Department of Anatomic Pathology and Cytology, Hotel-Dieu, University Denis Diderot, Paris, France., Nathwani BN; Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA., MacLennan KA; Section of Pathology and Leeds Institute of Molecular Medicine, St. James University Hospital, West Yorkshire, UK., Müller-Hermelink HK; Institute of Pathology, University of Würzburg, Würzburg, Germany., Bast M; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA., Boilesen E; Center for Collaboration on Research, Design and Analysis, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA., Armitage JO; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA., Weisenburger DD; Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2016 Mar; Vol. 172 (5), pp. 699-708. Date of Electronic Publication: 2015 Dec 18.
DOI: 10.1111/bjh.13876
Abstrakt: Comparative data regarding the distribution of non-Hodgkin lymphoma (NHL) subtypes in North Africa, the Middle East and India (NAF/ME/IN) is scarce in the literature. In this study, we evaluated the relative frequencies of NHL subtypes in this region. Five expert haematopathologists classified 971 consecutive cases of newly-diagnosed NHL from five countries in NAF/ME/IN. After review, 890 cases (91·7%) were confirmed to be NHL and compared to 399 cases from North America (NA). The male-to-female ratio was significantly higher in NAF/ME/IN (1·8) compared to NA (1·1; P< 0·05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in NAF/ME/IN (56 and 52 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). In NAF/ME/IN, a significantly lower proportion of LG B-NHL (28·4%) and a higher proportion of HG B-NHL (58·4%) were found compared to NA (56·1% and 34·3%, respectively). Diffuse large B-cell lymphoma was more common in NAF/ME/IN (49·4%) compared to NA (29·3%), whereas follicular lymphoma was less common in NAF/ME/IN (12·4%) than in NA (33·6%). In conclusion, we found significant differences in NHL subtypes and clinical features between NAF/ME/IN and NA. Epidemiological studies are needed to better understand the pathobiology of these differences.
(© 2015 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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