| Autor: |
Mirza IH; Department Medicine II, Southampton General Hospital, UK., Wilkin TJ |
| Jazyk: |
angličtina |
| Zdroj: |
International archives of allergy and applied immunology [Int Arch Allergy Appl Immunol] 1989; Vol. 89 (2-3), pp. 261-3. |
| DOI: |
10.1159/000234957 |
| Abstrakt: |
The immune response to insulin in Balb/c mice has been investigated with regard to the fine specificity of antibodies present during the primary stage of immune responsiveness. Hybridoma technology was used to raise monoclonal antibodies and a solid phase enzyme-linked immunoassay to test their specificity for human, bovine and porcine insulins. Heteroclitic antibodies were observed. These showed greater binding to the cross-reactive bovine and porcine insulins than to the inducing human insulin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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