Assessment of the Renal Function in Potential Donors of Living Kidney Transplants: Expanded Study.

Autor: Macías LB; UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain. Electronic address: lobama85@hotmail.com., Poblet MS; UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain., Pérez NN; UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain., Jerez RI; y Medicina Nuclear, Hospital Virgen del Rocío, Sevilla, Spain., Gonzalez Roncero FM; UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain., Blanco GB; UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain., Valdivia MA; UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain., Benjumea AS; UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain., Gentil Govantes MA; UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2015 Nov; Vol. 47 (9), pp. 2603-7.
DOI: 10.1016/j.transproceed.2015.09.029
Abstrakt: Introduction: It is very important to determine as accurately as possible the renal function in potential living renal transplant donors, especially those with limited renal function (CrCl <90 mL/m/1.73 m(2)), age older than 50 years, and cardiovascular risk factors that might favor the development of long-term kidney diseases.
Objective: The objective of this study was to compare the direct measurement of glomerular filtration rate (GFR) using EDTA-Cr51 and the estimations based on creatinine (eGFR): Cr clearance (CCr) with 24-hour urine and estimated using Cockroft-Gault (adjusted by using body surface area-Mosteller formula-SC), MDRD-4, MDRD-6, and CKD-EPI to determine the usefulness of different methods from EDTA-Cr51to evaluate the kidney function.
Patients and Methods: The kidney function evaluation has been made to 105 potential kidney donors using the EDTA-Cr51 method. The GFR obtained through the EDTA-Cr51 is compared with the CCr values in 24-hour urine and eGFR based on creatinine (Cockcroft-Gault, MDRD4, MDRD6, and CKD-EPI).
Results: Using the Bland Altman graphic we have observed that the most dispersed results are obtained with the eGFR using CCr in 24-hour urine and CKD-EPI. By means of Pasing & Bablock, we realized that MDRD-4 and MDRD-6 show the highest approximation to the reference method proposed to be substituted, whereas CCr shows a high dispersion.
Conclusions: eGFR using MDRD-4 and MDRD-6 formulas reveal the best adjustment to the measure by EDTA-Cr51. This might represent the best option if a direct eGFR measure is not available.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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