The baseline characteristics and interim analyses of the high-risk sentinel cohort of the Vietnam Initiative on Zoonotic InfectiONS (VIZIONS).

Autor:	Carrique-Mas JJ; Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7BN, United Kingdom., Tue NT; Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Global Viral, San Francisco, CA 94104 USA., Bryant JE; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7BN, United Kingdom.; National Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ha Noi, Vietnam., Saylors K; Global Viral, San Francisco, CA 94104 USA., Cuong NV; Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Hoa NT; Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7BN, United Kingdom., An NN; Preventive Medicine Centre Dong Thap Province, Cao Lanh, Vietnam., Hien VB; Sub-Department of Animal Health Dong Thap Province, Cao Lanh, Vietnam., Lao PV; Preventive Medicine Centre Dak Lak Province, Buon Ma Thuot, Vietnam., Tu NC; Regional Animal Health Laboratory 5, Buon Ma Thuot, Vietnam., Chuyen NK; Sub-Department of Animal Health Dak Lak Province, Buon Ma Thuot, Vietnam., Chuc NT; Hanoi Medical University, Ha Noi, Vietnam., Tan DV; Ba Vi District Health Centre, Ha Noi, Vietnam., Duong HV; Ba Vi District Veterinary Station, Ha Noi, Vietnam., Toan TK; Hanoi Medical University, Ha Noi, Vietnam., Chi NT; National Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ha Noi, Vietnam., Campbell J; Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7BN, United Kingdom., Rabaa MA; Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7BN, United Kingdom., Nadjm B; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7BN, United Kingdom.; National Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ha Noi, Vietnam., Woolhouse M; Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, United Kingdom., Wertheim H; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7BN, United Kingdom.; National Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ha Noi, Vietnam.; Department of Medical Microbiology, Radboud University Medical Cente, Nijmegen 6500 HB, the Netherlands., Thwaites G; Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7BN, United Kingdom., Baker S; Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7BN, United Kingdom.; London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2015 Dec 10; Vol. 5, pp. 17965. Date of Electronic Publication: 2015 Dec 10.
DOI:	10.1038/srep17965
Abstrakt:	The Vietnam Initiative for Zoonotic Infections (VIZIONS) includes community-based 'high-risk sentinel cohort' (HRSC) studies investigating individuals at risk of zoonotic infection due to occupational or residential exposure to animals. A total of 852 HRSC members were recruited between March 2013 and August 2014 from three provinces (Ha Noi, Dak Lak, and Dong Thap). The most numerous group (72.8%) corresponded to individuals living on farms, followed by slaughterers (16.3%) and animal health workers (8.5%). Nasal/pharyngeal and rectal swabs were collected from HRSC members at recruitment and after notifying illness. Exposure to exotic animals (including wild pigs, porcupine, monkey, civet, bamboo rat and bat) was highest for the Dak Lak cohort (53.7%), followed by Ha Noi (13.7%) and Dong Thap (4.0%). A total of 26.8% of individuals reported consumption of raw blood over the previous year; 33.6% slaughterers reported no use of protective equipment at work. Over 686 person-years of observation, 213 episodes of suspect infectious disease were notified, equivalent of 0.35 reports per person-year. Responsive samples were collected from animals in the farm cohort. There was noticeable time and space clustering of disease episodes suggesting that the VIZIONS set up is also suitable for the formal epidemiological investigation of disease outbreaks.
Databáze:	MEDLINE
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