Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value.

Autor: Eldridge MA; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland, USA., Lerchner W; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland, USA., Saunders RC; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland, USA., Kaneko H; Department of Molecular Neuroimaging, National Institute of Radiological Science, Chiba, Japan., Krausz KW; Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland, USA., Gonzalez FJ; Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland, USA., Ji B; Department of Molecular Neuroimaging, National Institute of Radiological Science, Chiba, Japan., Higuchi M; Department of Molecular Neuroimaging, National Institute of Radiological Science, Chiba, Japan., Minamimoto T; Department of Molecular Neuroimaging, National Institute of Radiological Science, Chiba, Japan., Richmond BJ; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland, USA.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2016 Jan; Vol. 19 (1), pp. 37-9. Date of Electronic Publication: 2015 Dec 14.
DOI: 10.1038/nn.4192
Abstrakt: To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.
Databáze: MEDLINE
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