Wellbeing and resilience: mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring--The WARM Study.

Autor: Harder S; Department of Psychology, University of Copenhagen, Copenhagen, Denmark. Susanne.Harder@psy.ku.dk., Davidsen K; Department of Child and Adolescent Mental Health Odense, Research Unit, Mental Health Services in the Region of Southern Denmark, Middelfart, Denmark. Kirstine.Agnete.Davidsen@rsyd.dk.; University of Southern Denmark, Odense, Denmark. Kirstine.Agnete.Davidsen@rsyd.dk., MacBeth A; School of Health in Social Science, University of Edinburgh, Edinburgh, Scotland, UK. amacbeth@exseed.ed.ac.uk., Lange T; Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark. thlan@sund.ku.dk., Minnis H; Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK. Helen.Minnis@glasgow.ac.uk., Andersen MS; University of Southern Denmark, Odense, Denmark. Marianne.Andersen1@rsyd.dk., Simonsen E; Psychiatric Research Unit, Psychiatry, Region Zealand, Roskilde, Denmark.; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lundy JM; Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK. Jenna-Marie.Lundy@glasgow.ac.uk., Nyström-Hansen M; Department of Psychology, University of Copenhagen, Copenhagen, Denmark. maja.hansen@psy.ku.dk., Trier CH; Department of Psychology, University of Copenhagen, Copenhagen, Denmark. christopher.trier@psy.ku.dk., Røhder K; Department of Psychology, University of Copenhagen, Copenhagen, Denmark. katrine.rohder@psy.ku.dk., Gumley A; Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK. Andrew.Gumley@glasgow.ac.uk.
Jazyk: angličtina
Zdroj: BMC psychiatry [BMC Psychiatry] 2015 Dec 09; Vol. 15, pp. 310. Date of Electronic Publication: 2015 Dec 09.
DOI: 10.1186/s12888-015-0692-6
Abstrakt: Unlabelled: The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age.
Background: Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction.
Methods/design: We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction.
Discussion: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.
Trial Registration: NCT02306551, date of registration November 12, 2014.
Databáze: MEDLINE
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