Screening determination of four amphetamine-type drugs in street-grade illegal tablets and urine samples by portable capillary electrophoresis with contactless conductivity detection.

Autor: Nguyen TA; Faculty of Chemistry, Department of Analytical Chemistry, Hanoi University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi, Viet Nam., Pham TN; Faculty of Chemistry, Department of Analytical Chemistry, Hanoi University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi, Viet Nam., Ta TT; Faculty of Chemistry, Department of Analytical Chemistry, Hanoi University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi, Viet Nam., Nguyen XT; Center of Drugs Expertise, Institute of Forensic Science, Ministry of Public Security, 99 Nguyen Tuan, Hanoi, Viet Nam., Nguyen TL; Faculty of Chemistry, Department of Analytical Chemistry, Hanoi University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi, Viet Nam., Le TH; National Institute for Food Control (NIFC), 13 Phan Huy Chu, Hanoi, Viet Nam., Koenka IJ; Department of Chemistry, University of Basel, Spitalstrasse 51, 4056 Basel, Switzerland., Sáiz J; University Institute of Research in Police Sciences (IUICP), University of Alcalá, Ctra. Madrid, Barcelona Km 33.6, 28871 Alcalá de Henares (Madrid), Spain., Hauser PC; Department of Chemistry, University of Basel, Spitalstrasse 51, 4056 Basel, Switzerland., Mai TD; Centre for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Nguyen Trai Street 334, Hanoi, Viet Nam. Electronic address: maithanhduc83@gmail.com.
Jazyk: angličtina
Zdroj: Science & justice : journal of the Forensic Science Society [Sci Justice] 2015 Dec; Vol. 55 (6), pp. 481-6. Date of Electronic Publication: 2015 Sep 26.
DOI: 10.1016/j.scijus.2015.09.001
Abstrakt: A simple and inexpensive method for the identification of four substituted amphetamines, namely, 3,4-methylenedioxy methamphetamine (MDMA), methamphetamine (MA), 3,4-methylenedioxy amphetamine (MDA) and 3,4-methylenedioxy-N-ethylamphetamine (MDEA) was developed using an in-house constructed semi-automated portable capillary electrophoresis instrument (CE) with capacitively coupled contactless conductivity detection (C(4)D). Arginine 10mM adjusted to pH4.5 with acetic acid was found to be the optimal background electrolyte for the CE-C(4)D determination of these compounds. The best detection limits achieved with and without a sample preconcentration process were 10ppb and 500ppb, respectively. Substituted amphetamines were found in different seized illicit club drug tablets and urine samples collected from different suspected users. Good agreement between results from CE-C(4)D and those with the confirmation method (GC-MS) was achieved, with correlation coefficients for the two pairs of data of more than 0.99.
(Copyright © 2015 The Chartered Society of Forensic Sciences. Published by Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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