Venous thromboembolism at time of diagnosis of ovarian cancer: Survival differs in symptomatic and asymptomatic cases.

Autor: Heath OM; Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Lanesborough Wing, St. George's Hospital, Blackshaw Road, London, SW17 0QT, United Kingdom. Electronic address: owenheath@doctors.org.uk., van Beekhuizen HJ; Department of Gynaecological Oncology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom., Nama V; Department of Gynaecological Oncology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom., Kolomainen D; Department of Gynaecological Oncology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom., Nobbenhuis MAE; Department of Gynaecological Oncology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom., Ind TEJ; Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Lanesborough Wing, St. George's Hospital, Blackshaw Road, London, SW17 0QT, United Kingdom; Department of Gynaecological Oncology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom., Sohaib SA; Department of Radiology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom., Lofts FJ; Department of Oncology, St. Georges Hospital, Blackshaw Road, London, SW17 0QT, United Kingdom., Heenan S; Department of Radiology, St. George's Hospital, Blackshaw Road, London, SW17 0QT, United Kingdom., Gore M; Department of Oncology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom., Banerjee S; Department of Oncology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom., Kaye SB; Department of Oncology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom., Barton DPJ; Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Lanesborough Wing, St. George's Hospital, Blackshaw Road, London, SW17 0QT, United Kingdom; Department of Gynaecological Oncology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom.
Jazyk: angličtina
Zdroj: Thrombosis research [Thromb Res] 2016 Jan; Vol. 137, pp. 30-35. Date of Electronic Publication: 2015 Nov 22.
DOI: 10.1016/j.thromres.2015.11.030
Abstrakt: Objectives: To determine the impact on survival of symptomatic and asymptomatic venous thromboembolism (VTE) at time of diagnosis of primary ovarian malignancy.
Materials and Methods: The clinical records of 397 consecutive cases of primary ovarian malignancy were studied. Clinical, pathological and survival data were obtained.
Results and Conclusions: Of 397 cases, 19 (4.8%) were found to have VTE at diagnosis, of which 63.2% (n=12) were asymptomatic. VTE was significantly associated with reduced overall median survival (28 vs. 45 months, p=0.004). Decreased survival was associated with symptomatic VTE compared to patients with asymptomatic VTE (21 vs. 36 months, p=0.02) whose survival was similar to that of patients without VTE. Decreased survival remained significant in symptomatic patients after controlling for stage of disease at diagnosis, cytoreductive status and adjuvant chemotherapy use. Overall these data suggest for the first time that symptomatic but not asymptomatic VTE prior to primary treatment of ovarian cancer is an independent adverse prognostic factor.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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