Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma.

Autor: Naito T; Department of Ophthalmology, Okayama University Graduate School of Medicine, Okayama, Japan., Yoshikawa K; Yoshikawa Eye Clinic, Tokyo, Japan., Mizoue S; Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, Tokyo, Japan., Nanno M; Kagurazaka Minamino Eye Clinic, Tokyo, Japan., Kimura T; Ueno Eye Clinic, Tokyo, Japan., Suzumura H; Suzumura Eye Clinic, Tokyo, Japan., Takeda R; Department of Agriculture, Kinki University, Nara, Japan., Shiraga F; Department of Ophthalmology, Okayama University Graduate School of Medicine, Okayama, Japan.
Jazyk: angličtina
Zdroj: Clinical ophthalmology (Auckland, N.Z.) [Clin Ophthalmol] 2015 Nov 26; Vol. 9, pp. 2217-22. Date of Electronic Publication: 2015 Nov 26 (Print Publication: 2015).
DOI: 10.2147/OPTH.S94497
Abstrakt: Purpose: To analyze the relationship between consecutive deterioration of mean deviation (MD) value and glaucomatous visual field (VF) progression in open-angle glaucoma (OAG), including primary OAG and normal tension glaucoma.
Patients and Methods: The subjects of the study were patients undergoing treatment for OAG who had performed VF tests at least 10 times with a Humphrey field analyzer (SITA standard, C30-2 program). The VF progression was defined by a significantly negative MD slope (MD slope worsening) at the final VF test during the follow-up period. The relationship between the MD slope worsening and the consecutive deterioration of MD value were retrospectively analyzed.
Results: A total of 165 eyes of 165 patients were included in the analysis. Significant progression of VF defects was observed in 72 eyes of 72 patients (43.6%), while no significant progression was evident in 93 eyes of 93 patients (56.4%). There was significant relationship between the frequency of consecutive deterioration of MD value and MD slope worsening (P<0.0001, Cochran-Armitage trend test). A significant association was observed for MD slope worsening in the eyes with three (odds ratio: 2.1, P=0.0224) and four (odds ratio: 3.6, P=0.0008) consecutive deterioration of MD value in multiple logistic regression analysis, but no significant association in the eyes with two consecutive deterioration (odds ratio: 1.1, P=0.8282). The eyes with VF progression had significantly lower intraocular pressure reduction rate (P<0.01).
Conclusion: This retrospective study has shown that three or more consecutive deterioration of MD value might be a predictor to future significant MD slope worsening in OAG.
Databáze: MEDLINE
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