Prevalence of lung structure abnormalities in patients with acromegaly and their relationship with gas exchange: cross-sectional analytical study with a control group.

Autor:	Rodrigues MP; School of Medicine, Universidade de Brasília, Brasília, Brasil., Naves LA; School of Medicine, Universidade de Brasília, Brasília, Brasil., Viegas CA; School of Medicine, Universidade de Brasília, Brasília, Brasil., Melo-Silva CA; Department of Pneumology, Hospital Universitário de Brasília, Brasília, Brasil., de Paula WD; Department of Radiology, Hospital Universitário de Brasília, Brasília, Brasil., Cabral MT; Department of Radiology, Hospital Universitário de Brasília, Brasília, Brasil., Araújo RR; Department of Pneumology, Hospital Universitário de Brasília, Brasília, Brasil., Casulari LA; Department of Endocrinology, Hospital Universitário de Brasília, Brasília, Brasil.
Jazyk:	angličtina
Zdroj:	Sao Paulo medical journal = Revista paulista de medicina [Sao Paulo Med J] 2015 Sep-Oct; Vol. 133 (5), pp. 394-400. Date of Electronic Publication: 2014 Sep 19.
DOI:	10.1590/1516-3180.2013.7640012
Abstrakt:	Context and Objective: Different functional respiratory alterations have been described in acromegaly, but their relationship with pulmonary tissue abnormalities is unknown. The objective of this study was to observe possible changes in lung structure and explain their relationship with gas exchange abnormalities. Design and Setting: Cross-sectional analytical study with a control group, conducted at a university hospital. Methods: The study included 36 patients with acromegaly and 24 controls who were all assessed through high-resolution computed tomography of the thorax (CT). Arterial blood gas, effort oximetry and serum growth hormone (GH) and insulin-like growth factor I (IGF-1) were also assessed in the patients with acromegaly. Results: The abnormalities found in the CT scan were not statistically different between the acromegaly and control groups: mild cylindrical bronchiectasis (P = 0.59), linear opacity (P = 0.29), nodular opacity (P = 0.28), increased attenuation (frosted glass; P = 0.48) and decreased attenuation (emphysema; P = 0.32). Radiographic abnormalities were not associated with serum GH and IGF-1. Hypoxemia was present in seven patients; however, in six of them, the hypoxemia could be explained by underlying clinical conditions other than acromegaly: chronic obstructive pulmonary disease in two, obesity in two, bronchial infection in one and asthma in one. Conclusion: No changes in lung structure were detected through thorax tomography in comparison with the control subjects. The functional respiratory alterations found were largely explained by alternative diagnoses or had subclinical manifestations, without any plausible relationship with lung structural factors.
Databáze:	MEDLINE
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