Elucidation on enhanced application of synthesised kojic acid immobilised magnetic and chitosan tri-polyphosphate nanoparticles as antibacterial agents.

Autor: Chaudhary J; Amity Institute of Biotechnology, Amity University Rajasthan, NH-11C, Kant Kalwar, Jaipur 303002, Rajasthan, India. jigneshchaudhary23@rediffmail.com., Lakhawat S; Amity Institute of Biotechnology, Amity University Rajasthan, NH-11C, Kant Kalwar, Jaipur 303002, Rajasthan, India., Pathak AN; Amity Institute of Biotechnology, Amity University Rajasthan, NH-11C, Kant Kalwar, Jaipur 303002, Rajasthan, India.
Jazyk: angličtina
Zdroj: IET nanobiotechnology [IET Nanobiotechnol] 2015 Dec; Vol. 9 (6), pp. 375-80.
DOI: 10.1049/iet-nbt.2014.0077
Abstrakt: Kojic acid (KA) is a secondary metabolite which is secreted by several aspergillus species. It is a multi-functional skeleton from which many derivatives can be synthesised and applied in various areas of biotechnology. KA grafting on synthesised magnetic nanoparticles (MNPs) and chitosan tri-polyphosphate (chitosan-TPP) nanoparticles was successfully done and characterised by Fourier transformation infrared spectroscopy. It was observed that amino propyl triethoxy silane-coated MNPs and chitosan-TPP nanoparticles enhanced the antibacterial activity of KA against both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa). The organic constitution and significant antibacterial activity of KA-chitosan-TPP nanoparticles can be applicable in the field of medical biotechnology.
Databáze: MEDLINE
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