Effects of Experimental Coma on the Expression of Bcl-2 Protein and Caspases 3 and 9 in Rat Brain.

Autor: Shvetsov AV; Laboratory of Genetics of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. svetsov83@mail.ru.; Laboratory of Biochemical Toxicology and Pharmacology, Institute of Toxicology, Federal Medical-Biological Agency of Russia, St. Petersburg, Russia. svetsov83@mail.ru., Dyuzhikova NA; Laboratory of Biochemical Toxicology and Pharmacology, Institute of Toxicology, Federal Medical-Biological Agency of Russia, St. Petersburg, Russia., Savenko YN; Laboratory of Biochemical Toxicology and Pharmacology, Institute of Toxicology, Federal Medical-Biological Agency of Russia, St. Petersburg, Russia., Batotsyrenova EG; Laboratory of Genetics of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia., Kashuro VA; Laboratory of Genetics of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 Dec; Vol. 160 (2), pp. 216-8. Date of Electronic Publication: 2015 Dec 08.
DOI: 10.1007/s10517-015-3132-1
Abstrakt: We performed immunohistochemical analysis of the expression of caspases 3, 9 and bcl-2 protein in rat brain at various terms after administration of LD50 of sodium thiopental. Expression of the specified apoptosis markers was found in the sensorimotor cortex and hippocampus (dentate gyrus and CA2 region).
Databáze: MEDLINE
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