Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity.

Autor: Christiansen M; a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark ., Hedley PL; a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark .; b Department of Biomedical Sciences , Stellenbosch University , Cape Town , South Africa ., Placing S; a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark ., Wøjdemann KR; c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .; d Department of Obstetrics and Gynecology , Roskilde Hospital , Roskilde , Denmark ., Carlsen AL; a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark ., Jørgensen JM; a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark ., Gjerris AC; c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .; e Department of Obstetrics and Gynecology , Hillerød Hospital , Hillerød , Denmark., Shalmi AC; c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .; e Department of Obstetrics and Gynecology , Hillerød Hospital , Hillerød , Denmark., Rode L; c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark ., Sundberg K; c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark ., Tabor A; c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .
Jazyk: angličtina
Zdroj: Hypertension in pregnancy [Hypertens Pregnancy] 2015 Nov; Vol. 34 (4), pp. 422-433. Date of Electronic Publication: 2015 Dec 04.
DOI: 10.3109/10641955.2014.913615
Abstrakt: Objective: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE).
Methods: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10 +0 -13 +6 .
Results: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length.
Conclusions: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.
Databáze: MEDLINE
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