Lower fasting blood glucose in neurofibromatosis type 1.

Autor:	Martins AS; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA., Jansen AK; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA., Rodrigues LO; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA., Matos CM; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA., Souza ML; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA., de Souza JF; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA., Diniz Mde F; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA., Barreto SM; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA., Diniz LM; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA., de Rezende NA; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA narezende@terra.com.br., Riccardi VM; Neurofibromatosis Outpatient Reference CenterFederal University of Minas Gerais, Alameda Álvaro Celso 55, Belo Horizonte, Minas Gerais, BrazilDepartment of Nutrition, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Medical Clinic, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Preventive and Social Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas GeraisProfessor Alfredo Balena Avenue, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, BrazilThe Neurofibromatosis Institute5415 Briggs Avenue, La Crescenta, CA, USA.
Jazyk:	angličtina
Zdroj:	Endocrine connections [Endocr Connect] 2016 Jan; Vol. 5 (1), pp. 28-33. Date of Electronic Publication: 2015 Dec 02.
DOI:	10.1530/EC-15-0102
Abstrakt:	Studies indicate a lower occurrence of diabetes mellitus (DM) in patients with neurofibromatosis type 1 (NF1). Fasting blood glucose (FBG) level is the main criterion used to diagnose DM and glucose intolerance. Therefore, this study compared FBG level between adults with NF1 and non-NF1 controls. We selected clinical records of 57 out of 701 individuals attending the Neurofibromatosis Outpatient Reference Center of the Clinics Hospital of the Federal University of Minas Gerais in Brazil. The selected patients with NF1 were matched to non-NF1 controls selected from the Brazilian Longitudinal Study of Adult Health according to sex, age (range, 35-74 years) and BMI at a ratio of 1:3. In both groups, individuals with DM were excluded. Median FBG level in the NF1 group (86 mg/dl (range, 56-127 mg/dl)) was lower than that in the non-NF1 control group (102 mg/dl (range, 85-146 mg/dl)) (P<0.001). Prevalence of FBG level ≥100 mg/dl in the NF1 group (16%) was lower than that in the non-NF1 control group (63%) (P<0.05). The chance of a high FBG level was 89% lower in the NF1 group (odds ratio, 0.112; 95% CI, 0.067-0.188) (P<0.05). In conclusion, adults with NF1 showed a lower FBG level and a lower prevalence of high FBG level compared with non-NF1 controls. (© 2016 The authors.)
Databáze:	MEDLINE
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