Transcatheter closure of the left atrial appendage: initial experience with the WATCHMAN device.

Autor:	Ding J; Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China., Zhu J; Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China., Lu J; Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China., Ding X; Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China., Zhang X; Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China., Lu W; Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China., Ao M; Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China., Ma G; Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China.
Jazyk:	angličtina
Zdroj:	International journal of clinical and experimental medicine [Int J Clin Exp Med] 2015 Sep 15; Vol. 8 (9), pp. 15230-7. Date of Electronic Publication: 2015 Sep 15 (Print Publication: 2015).
Abstrakt:	Background: Atrial fibrillation (AF) is the most commonly encountered clinical arrhythmia, accounting for approximately one third of hospitalizations for cardiac rhythm disturbance. In patients with non-valvular AF, approximately 90% of thrombi are thought to arise from the left atrial appendage (LAA). Anticoagulation with warfarin has been the mainstay of therapy to reduce stroke risk in these patients; however, it is not without its complications including bleeding and drug interactions. Percutaneous left atrial appendage closure can be an alternative to warfarin treatment in patients with AF at high risk for thromboembolic events and/or bleeding complications. Methods: Patients with atrial fibrillation and CHADSVASc score ≥ 2, not eligible for anticoagulation, were submitted to left atrial appendage closure using the WATCHMAN device. The procedure was performed under general anaesthesia, and was guided by fluoroscopy and transoesophageal echocardiography. Results: Percutaneous LAA closure with the WATCHMAN device was performed in all patients. At 45-day follow-up no recurrent major adverse events and especially no thromboembolic events occurred. Conclusions: Transcatheter closure of the LAA with the WATCHMAN device is generally safe and feasible. Long-term follow-up will further reveal the risk and benefits of this therapy.
Databáze:	MEDLINE
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