Reduced risk of pancreatic cancer associated with asthma and nasal allergies.

Autor:	Gomez-Rubio P; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Zock JP; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain., Rava M; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Marquez M; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Sharp L; National Cancer Registry Ireland, Cork, Ireland, and Institute of Health & Society, Newcastle University, UK., Hidalgo M; Hospital Madrid-Norte-Sanchinarro, Madrid, Spain., Carrato A; Department of Oncology, Hospital Ramón y Cajal, Madrid, Spain., Ilzarbe L; Hospital del Mar-Parc de Salut Mar, Barcelona, Spain., Michalski C; Technical University of Munich, Munich, Germany., Molero X; Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Farré A; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Perea J; Department of Surgery, 12 de Octubre University Hospital, Madrid, Spain., Greenhalf W; The Royal Liverpool University Hospital, Liverpool, UK., O'Rorke M; Centre for Public Health, Queen's University Belfast, Belfast, UK., Tardón A; Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain., Gress T; Department of Gastroenterology, University Hospital Giessen and Marburg, Marburg, Germany., Barberà V; Laboratorio de Genética Molecular, Hospital General Universitario de Elche, Elche, Spain., Crnogorac-Jurcevic T; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Domínguez-Muñoz E; Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain., Muñoz-Bellvís L; Cirugía General y del Aparato Digestivo, Hospital Universitario de Salamanca, Salamanca, Spain., Alvarez-Urturi C; Hospital del Mar-Parc de Salut Mar, Barcelona, Spain., Balcells J; Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Barneo L; Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain., Costello E; The Royal Liverpool University Hospital, Liverpool, UK., Guillén-Ponce C; Department of Oncology, Hospital Ramón y Cajal, Madrid, Spain., Kleeff J; Technical University of Munich, Munich, Germany., Kong B; Technical University of Munich, Munich, Germany., Lawlor R; Department of Pathology and Diagnostics, University of Verona, Verona, Italy., Löhr M; Gastrocentrum, Karolinska Institutet, Stockholm, Sweden., Mora J; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Murray L; Centre for Public Health, Queen's University Belfast, Belfast, UK., O'Driscoll D; National Cancer Registry Ireland, Cork, Ireland, and Institute of Health & Society, Newcastle University, UK., Peláez P; Department of Surgery, 12 de Octubre University Hospital, Madrid, Spain., Poves I; Hospital del Mar-Parc de Salut Mar, Barcelona, Spain., Scarpa A; Department of Pathology and Diagnostics, University of Verona, Verona, Italy., Real FX; Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Malats N; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Gut [Gut] 2017 Feb; Vol. 66 (2), pp. 314-322. Date of Electronic Publication: 2015 Dec 01.
DOI:	10.1136/gutjnl-2015-310442
Abstrakt:	Objective: Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk. Design: Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Meta-analyses of association studies on these diseases and PDAC risk were performed applying random-effects model. Results: Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly long-standing asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk. Conclusions: This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
Databáze:	MEDLINE
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