Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis.

Autor: Măluţan AM; 2 Department of Obstetrics and Gynecology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca 400610, Romania., Drugan T; Department of Medical Informatics and Biostatistics, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca 400610, Romania., Ciortea R; 2 Department of Obstetrics and Gynecology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca 400610, Romania., Mocan-Hognogi RF; 2 Department of Obstetrics and Gynecology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca 400610, Romania., Bucuri C; 2 Department of Obstetrics and Gynecology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca 400610, Romania., Rada MP; 2 Department of Obstetrics and Gynecology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca 400610, Romania., Mihu D; 2 Department of Obstetrics and Gynecology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca 400610, Romania.
Jazyk: angličtina
Zdroj: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences [J Res Med Sci] 2015 Jul; Vol. 20 (7), pp. 668-74.
DOI: 10.4103/1735-1995.166215
Abstrakt: Background: Endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. The present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls.
Materials and Methods: One hundred and sixty women were included, divided into two study groups (Group I - endometriosis; Group 2 - healthy women). We evaluated the serum levels of interleukin-1 receptor antagonist (IL-1Ra), IL-2, IL-2R, IL-4, IL-10, IL-13, and IL-15 with the use of Human multiplex cytokine panels. Statistical analyses (normality distribution analysis, independent t-test, Mann-Whitney U-test) were performed using IBM SPSS software (version 22.0) and GraphPad Prism (version 5.00); receiver operating characteristic curve were used to demonstrate the diagnostic performance of the studied markers.
Results: The mean serum level of IL-1Ra, IL-4, and IL-10 were significantly higher in women with endometriosis compared to women free of disease from the control group (30.155, 138.459, and 1.489, respectively, compared to 14.109, 84.710, and 0.688, respectively; P < 0.001, P < 0.001, and P = 0.002, respectively.). No significant differences in the mean serum levels of IL-2, IL-13, and IL-15 were observed between the studied groups and IL-2R had a very low detection rate.
Conclusion: Endometriosis is associated with elevated levels of anti-inflammatory cytokines, IL-1Ra, IL-4, and IL-10, markers that have a potential role as a prognostic factor for endometriosis.
Databáze: MEDLINE
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