| Autor: |
Phillip MJ; Department of Microbiology and Biochemistry, University of Detroit School of Dentistry, Mich., Maximuke PP |
| Jazyk: |
angličtina |
| Zdroj: |
Oncology [Oncology] 1989; Vol. 46 (4), pp. 266-72. |
| DOI: |
10.1159/000226729 |
| Abstrakt: |
A Chemiluminescent System (CLS), using a Peroxyoxalate chemiluminescent solution (PCs), together with Hematoporphyrin derivative (HpD) Photofrin II., were utilized in the treatment of transplanted mammary adenocarcinomas in C3H/HeJ female mice. Tumor bearing animals aged 2-4 months were divided into five groups; Group I was the control. Groups 2 and 4 compared the effectiveness of both reagents HpD and PCs which were administered by intratumor injections fractionated over a 96 hour period. Groups 3 and 5 compared the effectiveness of PCs alone. Tests of the PCs were conducted with and without the presence of luminescence. Fifty-three percent of the animals in Group 4 and 47% of the animals in Group 2 remained tumor free 120 days after the completion of treatment. Thirty percent of the animals in Groups 2 and 4 survived one year without tumor recurrence. The results of this study suggest that a chemical light system can be a viable alternative in Photodynamic Therapy (PDT) to laser light for the activation of HpD and treatment of cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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