Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells.

Autor: Carey AN; a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA.; b Department of Psychology , Simmons College , Boston , MA , USA., Miller MG; a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA., Fisher DR; a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA., Bielinski DF; a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA., Gilman CK; b Department of Psychology , Simmons College , Boston , MA , USA., Poulose SM; a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA., Shukitt-Hale B; a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA.
Jazyk: angličtina
Zdroj: Nutritional neuroscience [Nutr Neurosci] 2017 May; Vol. 20 (4), pp. 238-245. Date of Electronic Publication: 2015 Nov 30.
DOI: 10.1080/1028415X.2015.1115213
Abstrakt: Objectives: The present study was carried out to determine if lyophilized açaí fruit pulp (genus, Euterpe), rich in polyphenols and other bioactive antioxidant and anti-inflammatory phytochemicals, is efficacious in reversing age-related cognitive deficits in aged rats.
Methods: The diets of 19-month-old Fischer 344 rats were supplemented for 8 weeks with 2% Euterpe oleracea (EO), Euterpe precatoria (EP), or a control diet. Rats were tested in the Morris water maze and then blood serum from the rats was used to assess inflammatory responses of BV-2 microglial cells.
Results: After 8 weeks of dietary supplementation with 2% EO or EP, rats demonstrated improved working memory in the Morris water maze, relative to controls; however, only the EO diet improved reference memory. BV-2 microglial cells treated with blood serum collected from EO-fed rats produced less nitric oxide (NO) than control-fed rats. Serum from both EO- and EP-fed rats reduced tumor necrosis factor-alpha (TNF-α). There is a relationship between performance in the water maze and the production of NO and TNF-α by serum-treated BV-2 cells, such that serum from rats with better performance was more protective against inflammatory signaling.
Discussion: Protection of memory during aging by supplementation of lyophilized açaí fruit pulp added to the diet may result from its ability to influence antioxidant and anti-inflammatory signaling.
Databáze: MEDLINE
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