Guillain Barré syndrome (GBS): new insights in the molecular mimicry between C. jejuni and human peripheral nerve (HPN) proteins.

Autor: Loshaj-Shala A; Faculty of Pharmacy, University Ss. Cyril and Methodius, Skopje, Macedonia; Department of Pharmacy, Faculty of Medicine, University Hasan Prishtina, Pristina, Kosovo., Regazzoni L; Department of Pharmaceutical Sciences DISFARM, University of Milan, Milan, Italy., Daci A; Department of Pharmacy, Faculty of Medicine, University Hasan Prishtina, Pristina, Kosovo., Orioli M; Department of Pharmaceutical Sciences DISFARM, University of Milan, Milan, Italy., Brezovska K; Faculty of Pharmacy, University Ss. Cyril and Methodius, Skopje, Macedonia., Panovska AP; Faculty of Pharmacy, University Ss. Cyril and Methodius, Skopje, Macedonia., Beretta G; Department of Pharmaceutical Sciences DISFARM, University of Milan, Milan, Italy. Electronic address: giangiacomo.beretta@unimi.it., Suturkova L; Faculty of Pharmacy, University Ss. Cyril and Methodius, Skopje, Macedonia.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2015 Dec 15; Vol. 289, pp. 168-76. Date of Electronic Publication: 2015 Nov 10.
DOI: 10.1016/j.jneuroim.2015.11.005
Abstrakt: Profile and immunoreactivity of proteins from HPN tissue, and from Campylobacter jejuni (O:19) were investigated. Proteins were extracted, separated by SDS-PAGE, their cross reactivity monitored by Western blotting, and identified by nHPLC-nESI-HRMS analysis. Proteins from C. jejuni, at Mw ~70 KDa were chaperone/co-chaperone proteins (GroEL, DnaK and HtpG). In the corresponding HPN band were serum albumin, neurofilament light peptide, cytoskeletal keratins and one HSP 70 and one HSP60. These chaperones reciprocally share high primary sequence homology and conservation of their known epitopes. These findings suggest that HSP chaperones may be suitable candidates involved in the molecular mimicry triggering GBS.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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