Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles.

Autor: Bosch OJ; Department of Behavioural and Molecular Neurobiology, Institute of Zoology, University of Regensburg, 93053 Regensburg, Germany. Electronic address: oliver.bosch@ur.de., Dabrowska J; Department of Cellular and Molecular Pharmacology, Department of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064-3095, USA. Electronic address: joanna.dabrowska@rosalindfranklin.edu., Modi ME; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Harvard Medical School, Boston, MA 02115, USA; Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA. Electronic address: Meera.Modi@gmail.com., Johnson ZV; Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA; Silvio O. Conte Center for Oxytocin and Social Cognition, Emory University, Atlanta, GA 30322, USA. Electronic address: zjohnso2@gmail.com., Keebaugh AC; Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA. Electronic address: akeebaugh@mriinterventions.com., Barrett CE; Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA; Silvio O. Conte Center for Oxytocin and Social Cognition, Emory University, Atlanta, GA 30322, USA. Electronic address: cbarrett27@gmail.com., Ahern TH; Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA; Center for Behavioral Neuroscience, Department of Psychology, Quinnipiac University, Hamden, CT 06518, USA. Electronic address: todd.h.ahern@gmail.com., Guo J; Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA; Silvio O. Conte Center for Oxytocin and Social Cognition, Emory University, Atlanta, GA 30322, USA. Electronic address: jguo4@emory.edu., Grinevich V; Schaller Research Group on Neuropeptides, German Cancer Research Center DKFZ, Cell Network Cluster of Excellence, University of Heidelberg, 69120 Heidelberg, Germany. Electronic address: v.grinevich@dkfz-heidelberg.de., Rainnie DG; Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA; Silvio O. Conte Center for Oxytocin and Social Cognition, Emory University, Atlanta, GA 30322, USA. Electronic address: drainni@emory.edu., Neumann ID; Department of Behavioural and Molecular Neurobiology, Institute of Zoology, University of Regensburg, 93053 Regensburg, Germany., Young LJ; Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA; Silvio O. Conte Center for Oxytocin and Social Cognition, Emory University, Atlanta, GA 30322, USA. Electronic address: lyoun03@emory.edu.
Jazyk: angličtina
Zdroj: Psychoneuroendocrinology [Psychoneuroendocrinology] 2016 Feb; Vol. 64, pp. 66-78. Date of Electronic Publication: 2015 Nov 23.
DOI: 10.1016/j.psyneuen.2015.11.011
Abstrakt: Loss of a partner can have severe effects on mental health. Here we explore the neural mechanisms underlying increased passive stress-coping, indicative of depressive-like behavior, following the loss of the female partner in the monogamous male prairie vole. We demonstrate that corticotropin-releasing factor receptor 2 (CRFR2) in the nucleus accumbens shell mediates social loss-induced passive coping. Further, we show that partner loss compromises the oxytocin system through multiple mechanisms. Finally, we provide evidence for an interaction of the CRFR2 and oxytocin systems in mediating the emotional consequences of partner loss. Our results suggest that chronic activation of CRFR2 and suppression of striatal oxytocin signaling following partner loss result in an aversive emotional state that may share underlying mechanisms with bereavement. We propose that the suppression of oxytocin signaling is likely adaptive during short separations to encourage reunion with the partner and may have evolved to maintain long-term partnerships. Additionally, therapeutic strategies targeting these systems should be considered for treatment of social loss-mediated depression.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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