Peculiar Effects of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiac Chronotropy in Newborn Rats.

Autor: Zefirov TL; Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia. zefirovtl@mail.ru., Khisamieva LI; Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia., Ziyatdinova NI; Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia., Zefirov AL; Department of Normal Physiology, Kazan Federal Medical University, Kazan, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 Nov; Vol. 160 (1), pp. 6-8. Date of Electronic Publication: 2015 Nov 25.
DOI: 10.1007/s10517-015-3084-5
Abstrakt: We studied the effects of selective blockade of various subtypes of α2-adrenoceptors on cardiac chronotropy in newborn rats. This period in rats is characterized by the absence of adrenergic regulation of heart function. Blockade of α2A/D- and α2B-adrenoceptors in 1-weekold rats provoked tachycardia. In contrast, blockade of α2C-adrenoceptors in newborn rats had no effect on heart rate.
Databáze: MEDLINE
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