Intracellular antigens as targets for antibody based immunotherapy of malignant diseases.

Autor: Wang Y; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Wang X; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Ferrone CR; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Schwab JH; Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Ferrone S; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States; Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States. Electronic address: sferrone@mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Molecular oncology [Mol Oncol] 2015 Dec; Vol. 9 (10), pp. 1982-93. Date of Electronic Publication: 2015 Oct 30.
DOI: 10.1016/j.molonc.2015.10.019
Abstrakt: This review discusses the potential use of intracellular tumor antigens as targets of antibody-based immunotherapy for the treatment of solid tumors. In addition, it describes the characteristics of the intracellular tumor antigens targeted with antibodies which have been described in the literature and have been identified in the authors' laboratory. Finally, the mechanism underlying the trafficking of the intracellular tumor antigens to the plasma membrane of tumor cells are reviewed.
(Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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