| Autor: |
Al-Nimer MS; Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq., Hameed HG; Department of Clinical Pharmacy, Al-Yarmouk Teaching Hospital, Ministry of Health, Baghdad, Iraq., Mahmood MM; Department of Biology, College of Science, Al-Mustansiriya University, Baghdad, Iraq. |
| Jazyk: |
angličtina |
| Zdroj: |
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2015 Oct; Vol. 23 (5), pp. 483-6. Date of Electronic Publication: 2015 Jan 10. |
| DOI: |
10.1016/j.jsps.2015.01.002 |
| Abstrakt: |
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of several cancer cell lines. The aim of this study is to compare the cytotoxic effect of aspirin with diclofenac on the growth of HeLa cell, mammary cell carcinoma, rhabdomyosarcoma and fibroblast cell lines in the culture media. The cells are cultured in RPMI-1640 culture media supplemented with 5% fetal calf serum and antibiotics. Aspirin (5 mg/well) and diclofenac (0.625 mg/well) significantly inhibit the growth of HeLa, rhabdomyosarcoma and fibroblast cells. The cytotoxic effect of aspirin against rhabdomyosarcoma is significantly (p < 0.001) higher than that of diclofenac with a potency approximated 2.6. It concludes that aspirin and diclofenac inhibit the growth of fibroblast and cancer cell by inhibiting the up-regulation of cyclooxygenases enzymes in cancer cells. Aspirin is more effective than diclofenac against the growth of rhabdomyosarcoma cell line. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
