Hand-portable liquid chromatographic instrumentation.

Autor: Sharma S; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Tolley LT; Department of Chemistry, Southern Illinois University, Carbondale, IL 62901, USA., Tolley HD; Department of Statistics, Brigham Young University, Provo, UT 84602, USA., Plistil A; VICI Valco Instruments, Houston, Texas 77055, USA., Stearns SD; VICI Valco Instruments, Houston, Texas 77055, USA., Lee ML; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA. Electronic address: milton_lee@byu.edu.
Jazyk: angličtina
Zdroj: Journal of chromatography. A [J Chromatogr A] 2015 Nov 20; Vol. 1421, pp. 38-47. Date of Electronic Publication: 2015 Aug 04.
DOI: 10.1016/j.chroma.2015.07.119
Abstrakt: Over the last four decades, liquid chromatography (LC) has experienced an evolution to smaller columns and particles, new stationary phases and low flow rate instrumentation. However, the development of person-portable LC has not followed, mainly due to difficulties encountered in miniaturizing pumps and detectors, and in reducing solvent consumption. The recent introduction of small, non-splitting pumping systems and UV-absorption detectors for use with capillary columns has finally provided miniaturized instrumentation suitable for high-performance hand-portable LC. Fully integrated microfabricated LC still remains a significant challenge. Ion chromatography (IC) has been successfully miniaturized and applied for field analysis; however, applications are mostly limited to inorganic and small organic ions. This review covers advancements that make possible more rapid expansion of portable forms of LC and IC.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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