| Autor: |
Akhmetshina MR, Berdalin AB, Morozova MP, Buravkov SV, Bespalova ZhD, Sidorova MV, Aref'eva TI, Krasnikova TL, Gavrilova SA |
| Jazyk: |
ruština |
| Zdroj: |
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2015 Jul; Vol. 101 (7), pp. 789-803. |
| Abstrakt: |
Monocyte chemotactic protein-1 (MCP-1) is a chemokine that stimulates monocytes and macrophage migration into the sites of acute of chronic inflammation. Our study shows morphological changes in ischemic myocardium followed by the administration of two synthetic structural fragments of MCP-1 that are monocyte/macrophage migration inductor peptide IX and peptide X an inhibitor. Results show that peptides can change time points of the inflammatory response in myocardium. Peptide IX administration leads to increased and accelerated inflammatory response, i. e. attracts an additional number of monocytes and macrophages into the inflammatory focus. The introduction of the peptide X observed prolonged inflammatory process with the overall gain signs of myocardial damage. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
