Childhood trauma and clinical outcome in patients at ultra-high risk of transition to psychosis.

Autor: Kraan T; Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands. Electronic address: t.kraan@parnassia.nl., van Dam DS; Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands., Velthorst E; Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands; Department of Psychiatry, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands; Departments of Psychiatry and Preventive Medicine, Icahn School of Medicine, Mount Sinai, New York, NY, USA., de Ruigh EL; Department of Psychiatry, VU University Medical Center Amsterdam, the Netherlands., Nieman DH; Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands., Durston S; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., Schothorst P; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., van der Gaag M; Department of Clinical Psychology, VU University, Amsterdam, the Netherlands; Department of Psychiatry, Parnassia Psychiatric Institute, The Hague, the Netherlands., de Haan L; Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands; Arkin Institute for Mental Health, Amsterdam, the Netherlands.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2015 Dec; Vol. 169 (1-3), pp. 193-198. Date of Electronic Publication: 2015 Nov 14.
DOI: 10.1016/j.schres.2015.10.030
Abstrakt: Background: Although transition rates in 'ultra-high risk' (UHR) for psychosis samples are declining, many young individuals at UHR still experience attenuated positive symptoms and impaired functioning at follow-up. The present study examined the association between a history of childhood trauma and transition to psychosis, and symptomatic and functional outcome, in UHR patients.
Method: Data on childhood trauma were available for 125 UHR individuals. Cox regression and linear regression analyses were used to determine the association between childhood trauma, and clinical and functional outcome, during the 24-month follow-up.
Results: Of the 125 UHR subjects 26 individuals (20.8%) transitioned to psychosis within 24 months. Childhood trauma did not predict transition to psychosis. However, at 24-month follow-up, UHR patients with higher levels of childhood trauma had higher levels of attenuated positive symptoms (b = 0.34, t = 2.925, p < 0.01), general symptoms (b = 0.29, t = 2.707, p < 0.01) and depression (b = 0.32, t = 2.929, p < 0.01) and lower levels of global functioning (b = − 0.33, t = − 2.853, p = 0.01). Childhood trauma was not significantly associated with a differential course of symptoms over time, although in those with higher levels of childhood trauma, attenuated positive symptoms were more persistent at a trend level.
Conclusions: Our results suggest that childhood trauma may contribute to a shared vulnerability for several psychopathological domains.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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