Parathyroid Imaging with Simultaneous Acquisition of 99mTc-Sestamibi and 123I: The Relative Merits of Pinhole Collimation and SPECT/CT.

Autor:	Bhatt PR; Division of Nuclear Medicine, Department of Radiology, University of Colorado School of Medicine, Aurora, Colorado paraag.bhatt@ucdenver.edu., Klingensmith WC 3rd; Division of Nuclear Medicine, Department of Radiology, University of Colorado School of Medicine, Aurora, Colorado., Bagrosky BM; Division of Nuclear Medicine, Department of Radiology, University of Colorado School of Medicine, Aurora, Colorado., Walter JC; Division of Nuclear Medicine, Department of Radiology, University of Colorado School of Medicine, Aurora, Colorado., McFann KK; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado; and., McIntyre RC Jr; Division of GI, Tumor and Endocrine Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado., Raeburn CD; Division of GI, Tumor and Endocrine Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado., Koo PJ; Division of Nuclear Medicine, Department of Radiology, University of Colorado School of Medicine, Aurora, Colorado.
Jazyk:	angličtina
Zdroj:	Journal of nuclear medicine technology [J Nucl Med Technol] 2015 Dec; Vol. 43 (4), pp. 275-81. Date of Electronic Publication: 2015 Nov 19.
DOI:	10.2967/jnmt.115.164939
Abstrakt:	Unlabelled: The objective of this study was to determine the relative utility of 3 state-of-the-art parathyroid imaging protocols: single-time-point simultaneous acquisition of (99m)Tc-sestamibi and (123)I images with pinhole collimation in the anterior and bilateral anterior oblique projections, single-time-point simultaneous acquisition of (99m)Tc-sestamibi and (123)I images with SPECT/CT, and the combination of the first and second protocols. Methods: Fifty-nine patients with surgical proof of parathyroid adenomas were evaluated retrospectively. All 3 protocols included perfectly coregistered subtraction images created by subtracting the (123)I images from the (99m)Tc-sestamibi images, plus an anterior parallel-hole collimator image of the neck and upper chest. The pinhole protocol was performed first, followed by the SPECT/CT protocol. Three image sets were derived from each study in each patient according to the above protocols. Two experienced observers recorded the size, location, and degree of certainty of any identified lesion. Results: The 59 patients had 61 adenomas. For the 2 observers combined, the localization success rate was 88% for the pinhole protocol, 69% for the SPECT/CT protocol, and 81% for the combined protocol. The pinhole protocol detected more adenomas than the SPECT/CT protocol and missed fewer adenomas than either the SPECT/CT protocol or the combined pinhole and SPECT/CT protocol (P < 0.01). The 2 protocols that included SPECT/CT provided superior anatomic information relative to the location and size of the parathyroid adenomas. Conclusion: The pinhole protocol localized significantly more adenomas than the SPECT/CT protocol. However, the protocols that included SPECT/CT provided more anatomic information than pinhole imaging alone. (© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.)
Databáze:	MEDLINE
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