Systemic and coronary levels of CRP, MPO, sCD40L and PlGF in patients with coronary artery disease.

Autor: Fong SW; School of Health Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia. fsw_1129@yahoo.com.my., Few LL; School of Health Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia. fewling@usm.my., See Too WC; School of Health Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia. stweicun@usm.my., Khoo BY; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Penang, Malaysia. boonyin@usm.my., Nik Ibrahim NN; School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia. izah@usm.my., Yahaya SA; National Heart Institute, 50400, Kuala Lumpur, Malaysia. shaifuly@ijn.com.my., Yusof Z; School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia. zurkurnai@usm.my., Mohd Ali R; National Heart Institute, 50400, Kuala Lumpur, Malaysia. rosli@ijn.com.my., Abdul Rahman AR; Cyberjaya University College of Medical Sciences, 63000, Cyberjaya, Selangor, Malaysia. rashid@cybermed.edu.my., Yvonne-Tee GB; School of Health Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia. yvonnetee@usm.my.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2015 Nov 14; Vol. 8, pp. 679. Date of Electronic Publication: 2015 Nov 14.
DOI: 10.1186/s13104-015-1677-8
Abstrakt: Background: Biomarkers play a pivotal role in the diagnosis and management of patients with acute coronary syndrome. This study aimed to investigate the differences in level of several biomarkers, i.e. C-reactive protein, myeloperoxidase, soluble CD40 ligand and placental growth factor, between acute coronary syndrome and chronic stable angina patients. The relationship between these biomarkers in the coronary circulation and systemic circulation was also investigated.
Methods: A total of 79 patients were recruited in this study. The coronary blood was sampled from occluded coronary artery, while the peripheral venous blood was withdrawn from antecubital fossa. The serum concentrations of C-reactive protein, soluble CD40 ligand and placental growth factor and plasma concentration of myeloperoxidase were measured using ELISA method.
Results: The systemic level of the markers measured in the peripheral venous blood was significantly increased in acute coronary syndrome compared to chronic stable angina patients. The concentrations of the C-reactive protein, myeloperoxidase and soluble CD40 ligand taken from peripheral vein were closely similar to the concentration found in coronary blood of ACS patients. The level of placental growth factor was significantly higher in coronary circulation than its systemic level.
Conclusion: The concentration of these C-reactive protein, myeloperoxidase, soluble CD40 ligand and placental growth factor were significantly increased in acute coronary syndrome patients. The concentration of the markers measured in the systemic circulation directly reflected those in the local coronary circulation. Thus, these markers have potential to become a useful tool in predicting plaque vulnerability in the future.
Databáze: MEDLINE
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