| Autor: |
Jupin M; Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Gamliel A; Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Hovav Y; Weizmann Institute of Science, Rehovot, Israel., Sosna J; Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Gomori JM; Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Katz-Brull R; Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. |
| Abstrakt: |
In the dissolution-dynamic nuclear polarization technique, molecular probes with long T 1s are preferred. 13C nuclei of small molecules with no directly bonded protons or sp(3 13)C nuclei with proton positions substituted by deuterons may fulfill this requirement. The T 1 determination of such new molecular probes is crucial for the success of the hyperpolarized observation. Although the inversion-recovery approach remained by and large the standard for T 1 measurements, we show here that the steady-state variable nutation angle approach is faster and may be better suited for the determination of relatively long T 1s in thermal equilibrium. Specifically, the T 1 of a new molecular probe, [uniformly labeled (UL)-13C6, UL-2H8]2-deoxy-d-glucose, is determined here and compared to that of [UL-13C6, UL-2H7]d-glucose. |
