| Autor: |
Bansal AK; Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India., Pande V; Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pharmaceutics [J Pharm (Cairo)] 2013; Vol. 2013, pp. 906178. Date of Electronic Publication: 2012 Dec 09. |
| DOI: |
10.1155/2013/906178 |
| Abstrakt: |
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text