Microwave-assisted solid-phase synthesis of side-chain to side-chain lactam-bridge cyclic peptides.

Autor: Tala SR; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA., Schnell SM; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA., Haskell-Luevano C; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: chaskell@umn.edu.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Dec 15; Vol. 25 (24), pp. 5708-11. Date of Electronic Publication: 2015 Oct 31.
DOI: 10.1016/j.bmcl.2015.10.095
Abstrakt: Side-chain to side-chain lactam-bridged cyclic peptides have been utilized as therapeutic agents and biochemical tools. Previous synthetic methods of these peptides need special reaction conditions, form side products and take longer reaction times. Herein, an efficient microwave-assisted synthesis of side-chain to side-chain lactam-bridge cyclic peptides SHU9119 and MTII is reported. The synthesis time and efforts are significantly reduced in the present method, without side product formation. The analytical and pharmacological data of the synthesized cyclic peptides are in accordance with the commercially obtained compounds. This new method could be used to synthesize other side-chain to side-chain lactam-bridge peptides and amenable to automation and extensive SAR compound derivatization.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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