Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels.

Autor: Annabi N; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.; Department of Chemical Engineering, Northeastern University, Boston, MA, 02115-5000, USA., Shin SR; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA., Tamayol A; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA., Miscuglio M; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Bakooshli MA; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Assmann A; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.; Department of Cardiovascular Surgery, Heinrich Heine University, 40225, Düsseldorf, Germany., Mostafalu P; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Sun JY; Department of Material Science and Engineering, Seoul National University, Seoul, 151-742, South Korea., Mithieux S; Molecular Bioscience, Charles Perkins Centre, Bosch Institute, University of Sydney, Sydney, NSW, 2006, Australia., Cheung L; Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada., Tang XS; Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada., Weiss AS; Molecular Bioscience, Charles Perkins Centre, Bosch Institute, University of Sydney, Sydney, NSW, 2006, Australia., Khademhosseini A; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.; Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2016 Jan 06; Vol. 28 (1), pp. 40-9. Date of Electronic Publication: 2015 Nov 09.
DOI: 10.1002/adma.201503255
Abstrakt: A highly elastic hybrid hydrogel of methacryloyl-substituted recombinant human tropoelastin (MeTro) and graphene oxide (GO) nanoparticles are developed. The synergistic effect of these two materials significantly enhances both ultimate strain (250%), reversible rotation (9700°), and the fracture energy (38.8 ± 0.8 J m(-2) ) in the hybrid network. Furthermore, improved electrical signal propagation and subsequent contraction of the muscles connected by hybrid hydrogels are observed in ex vivo tests.
(© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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