Nocturnal eczema: Review of sleep and circadian rhythms in children with atopic dermatitis and future research directions.

Autor: Fishbein AB; Department of Pediatrics, Division of Allergy and Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Ill. Electronic address: afishbein@luriechildrens.org., Vitaterna O; Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Ill., Haugh IM; Departments of Dermatology and Pediatrics, Northwestern University, Chicago, Ill., Bavishi AA; Department of Pediatrics, Division of Allergy and Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Ill., Zee PC; Department of Neurology and the Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill., Turek FW; Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Ill., Sheldon SH; Department of Pediatrics, Division of Sleep & Pulmonology, Northwestern University, Chicago, Ill., Silverberg JI; Departments of Dermatology and Pediatrics, Northwestern University, Chicago, Ill., Paller AS; Departments of Dermatology and Pediatrics, Northwestern University, Chicago, Ill.
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2015 Nov; Vol. 136 (5), pp. 1170-7.
DOI: 10.1016/j.jaci.2015.08.028
Abstrakt: Children with atopic dermatitis (AD) experience significant sleep disruption, and clinically, the disease is noted to worsen in a circadian manner at night. Epidemiologic findings highlight many negative consequences of AD, such as impaired linear growth, which is uniquely related to disturbed sleep. Clinical guidelines currently recommend assessing sleep in patients with AD as a crucial parameter of disease control with appropriate treatment. In this review we describe our current understanding of the roles of sleep cycles and circadian rhythms in the nighttime exacerbation of AD (nocturnal eczema). We present a schematic to explain the mechanism of nocturnal eczema. Treatment options for sleep disturbance and future directions for research are discussed in the context of AD.
(Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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