Vicarious social defeat stress: Bridging the gap between physical and emotional stress.

Autor: Sial OK; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306-4301, United States., Warren BL; National Institute on Drug Abuse, Behavioral Neuroscience Research Branch, Baltimore, MD, United States., Alcantara LF; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306-4301, United States., Parise EM; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306-4301, United States., Bolaños-Guzmán CA; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306-4301, United States. Electronic address: bolanos@psy.fsu.edu.
Jazyk: angličtina
Zdroj: Journal of neuroscience methods [J Neurosci Methods] 2016 Jan 30; Vol. 258, pp. 94-103. Date of Electronic Publication: 2015 Nov 03.
DOI: 10.1016/j.jneumeth.2015.10.012
Abstrakt: Background: Animal models capable of differentiating the neurobiological intricacies between physical and emotional stress are scarce. Current models rely primarily on physical stressors (e.g., chronic unpredictable or mild stress, social defeat, learned helplessness), and neglect the impact of psychological stress alone. This is surprising given extensive evidence that a traumatic event needs not be directly experienced to produce enduring perturbations on an individual's health and psychological well-being. Post-traumatic stress disorder (PTSD), a highly debilitating neuropsychiatric disorder characterized by intense fear of trauma-related stimuli, often occurs in individuals that have only witnessed a traumatic event.
New Method: By modifying the chronic social defeat stress (CSDS) paradigm to include a witness component (witnessing the social defeat of another mouse), we demonstrate a novel behavioral paradigm capable of inducing a robust behavioral syndrome reminiscent of PTSD in emotionally stressed adult mice.
Results: We describe the vicarious social defeat stress (VSDS) model that is capable of inducing a host of behavioral deficits that include social avoidance and other depressive- and anxiety-like phenotypes in adult male mice. VSDS exposure induces weight loss and spike in serum corticosterone (CORT) levels. A month after stress, these mice retain the social avoidant phenotype and have an increased CORT response when exposed to subsequent stress.
Comparison With Existing Method(s): The VSDS is a novel paradigm capable of inducing emotional stress by isolating physical stress/confrontation in mice.
Conclusions: The VSDS model can be used to study the short- and long-term neurobiological consequences of exposure to emotional stress in mice.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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