Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients: Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters.

Autor: Cabassi A; Cardiorenal Research Unit, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy ; Laboratory of Experimental Physiopathology, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy., Binno SM; Cardiorenal Research Unit, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy., Tedeschi S; Cardiorenal Research Unit, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy., Graiani G; Dentistry School, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy., Galizia C; Cardiorenal Research Unit, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy., Bianconcini M; Cardiology Clinic, Azienda Ospedaliera-Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy., Coghi P; Cardiorenal Research Unit, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy ; Laboratory of Experimental Physiopathology, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy., Fellini F; Cardiorenal Research Unit, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy., Ruffini L; Nuclear Medicine Unit, Azienda Ospedaliera-Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy., Govoni P; Histology and Embryology Unit, Department of Biomedical, Biotechnological and Translational Sciences, University of Parma Medical School, Italy., Piepoli M; Heart Failure Unit, Cardiology Department, Guglielmo da Saliceto Hospital, Piacenza, Italy., Perlini S; Department of Internal Medicine, University of Pavia, Italy., Regolisti G; Cardiorenal Research Unit, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy., Fiaccadori E; Cardiorenal Research Unit, Department of Clinical and Experimental Medicine, University of Parma Medical School, Italy.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 691693. Date of Electronic Publication: 2015 Oct 11.
DOI: 10.1155/2015/691693
Abstrakt: Rationale: Heart failure (HF) is accompanied by the development of an imbalance between oxygen- and nitric oxide-derived free radical production leading to protein nitration. Both chlorinating and peroxidase cycle of Myeloperoxidase (MPO) contribute to oxidative and nitrosative stress and are involved in tyrosine nitration of protein. Ceruloplasmin (Cp) has antioxidant function through its ferroxidase I (FeOxI) activity and has recently been proposed as a physiological defense mechanism against MPO inappropriate actions.
Objective: We investigated the relationship between plasma MPO-related chlorinating activity, Cp and FeOxI, and nitrosative stress, inflammatory, neurohormonal, and nutritional biomarkers in HF patients.
Methods and Results: In chronic HF patients (n = 81, 76 ± 9 years, NYHA Class II (26); Class III (29); Class IV (26)) and age-matched controls (n = 17, 75 ± 11 years, CTR), plasma MPO chlorinating activity, Cp, FeOxI, nitrated protein, free Malondialdehyde, BNP, norepinephrine, hsCRP, albumin, and prealbumin were measured. Plasma MPO chlorinating activity, Cp, BNP, norepinephrine, and hsCRP were increased in HF versus CTR. FeOxI, albumin, and prealbumin were decreased in HF. MPO-related chlorinating activity was positively related to Cp (r = 0.363, P < 0.001), nitrated protein, hsCRP, and BNP and inversely to albumin.
Conclusions: Plasma MPO chlorinated activity is increased in elderly chronic HF patients and positively associated with Cp, inflammatory, neurohormonal, and nitrosative parameters suggesting a role in HF progression.
Databáze: MEDLINE
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