Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.

Autor:	Hunt JB Jr; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Nash KR; Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33613., Placides D; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Moran P; Byrd Alzheimer's Institute., Selenica ML; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Abuqalbeen F; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Ratnasamy K; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Slouha N; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Rodriguez-Ospina S; Byrd Alzheimer's Institute., Savlia M; Byrd Alzheimer's Institute., Ranaweera Y; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Reid P; Byrd Alzheimer's Institute., Dickey CA; Byrd Alzheimer's Institute., Uricia R; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Yang CG; Morsani College of Medicine, University of South Florida, Tampa, Florida 33613., Sandusky LA; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Gordon MN; Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33613., Morgan D; Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33613., Lee DC; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and dlee1@health.usf.edu.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2015 Nov 04; Vol. 35 (44), pp. 14842-60.
DOI:	10.1523/JNEUROSCI.3959-14.2015
Abstrakt:	Tau accumulation remains one of the closest correlates of neuronal loss in Alzheimer's disease. In addition, tau associates with several other neurodegenerative diseases, collectively known as tauopathies, in which clinical phenotypes manifest as cognitive impairment, behavioral disturbances, and motor impairment. Polyamines act as bivalent regulators of cellular function and are involved in numerous biological processes. The regulation of the polyamines system can become dysfunctional during disease states. Arginase 1 (Arg1) and nitric oxide synthases compete for l-arginine to produce either polyamines or nitric oxide, respectively. Herein, we show that overexpression of Arg1 using adeno-associated virus (AAV) in the CNS of rTg4510 tau transgenic mice significantly reduced phospho-tau species and tangle pathology. Sustained Arg1 overexpression decreased several kinases capable of phosphorylating tau, decreased inflammation, and modulated changes in the mammalian target of rapamycin and related proteins, suggesting activation of autophagy. Arg1 overexpression also mitigated hippocampal atrophy in tau transgenic mice. Conversely, conditional deletion of Arg1 in myeloid cells resulted in increased tau accumulation relative to Arg1-sufficient mice after transduction with a recombinant AAV-tau construct. These data suggest that Arg1 and the polyamine pathway may offer novel therapeutic targets for tauopathies. (Copyright © 2015 the authors 0270-6474/15/3514842-19$15.00/0.)
Databáze:	MEDLINE
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