Effects of scratching and other counterstimuli on responses of trigeminothalamic tract neurons to itch-inducing stimuli in rats.
| Autor: | Lipshetz B; Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota., Giesler GJ Jr; Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota giesler@umn.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of neurophysiology [J Neurophysiol] 2016 Jan 01; Vol. 115 (1), pp. 520-9. Date of Electronic Publication: 2015 Nov 04. |
| DOI: | 10.1152/jn.00326.2015 |
| Abstrakt: | Counterstimuli such as scratching, pinching, noxious heat and cold, and innocuous cooling and warming have been shown to inhibit itch in humans. In the present study, the effects of each of these counterstimuli were determined on baseline firing rates and on sustained pruriceptive responses of rat trigeminothalamic tract neurons. We found that scratching had little, if any, effect on baseline firing levels but greatly reduced mean pruriceptive firing following scratching for nearly 1 min. None of the other noxious or innocuous counterstimuli significantly inhibited pruriceptive responses. Our results indicate that scratching, but not other counterstimuli, significantly reduces itch-induced responses of trigeminothalamic tract neurons. (Copyright © 2016 the American Physiological Society.) |
| Databáze: | MEDLINE |
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