A Betabaculovirus-Encoded gp64 Homolog Codes for a Functional Envelope Fusion Protein.

Autor:	Ardisson-Araújo DM; Laboratory of Baculovirus, Cell Biology Department, University of Brasilia, Brasilia, DF, Brazil Division of Biology, Kansas State University, Manhattan, Kansas, USA., Melo FL; Laboratory of Baculovirus, Cell Biology Department, University of Brasilia, Brasilia, DF, Brazil., Clem RJ; Division of Biology, Kansas State University, Manhattan, Kansas, USA., Wolff JL; Laboratory of Molecular Biology and Virology, Biological Science and Health Center, Mackenzie Presbyterian University, Sao Paulo, SP, Brazil., Ribeiro BM; Laboratory of Baculovirus, Cell Biology Department, University of Brasilia, Brasilia, DF, Brazil bergmann@unb.br.
Jazyk:	angličtina
Zdroj:	Journal of virology [J Virol] 2015 Nov 04; Vol. 90 (3), pp. 1668-72. Date of Electronic Publication: 2015 Nov 04 (Print Publication: 2016).
DOI:	10.1128/JVI.02491-15
Abstrakt:	The GP64 envelope fusion protein is a hallmark of group I alphabaculoviruses. However, the Diatraea saccharalis granulovirus genome sequence revealed the first betabaculovirus species harboring a gp64 homolog (disa118). In this work, we have shown that this homolog encodes a functional envelope fusion protein and could enable the infection and fusogenic abilities of a gp64-null prototype baculovirus. Therefore, GP64 may complement or may be in the process of replacing F protein activity in this virus lineage. (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu