A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease.

Autor: Altman IA; Department of Surgery, Section of Wound Healing and Tissue Repair, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA., Kleinfelder RE; Traditional Rotating Internship, Genesys Regional Medical Center, Grand Blanc, MI, USA., Quigley JG; Department of Hematology and Medical Oncology, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA., Ennis WJ; Department of Surgery, Section of Wound Healing and Tissue Repair, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA., Minniti CP; Department of Oncology, Division of Hematology, Sickle Cell Center, Montefiore Medical Center, Bronx, NY, USA.
Jazyk: angličtina
Zdroj: International wound journal [Int Wound J] 2016 Dec; Vol. 13 (6), pp. 1315-1324. Date of Electronic Publication: 2015 Nov 04.
DOI: 10.1111/iwj.12522
Abstrakt: Sickle cell leg ulcers (SCLUs) are a common complication of sickle cell disease (SCD). Patients who develop ulcers appear to have a more severe haemolysis-associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. SCLUs are slow to heal and often recur, affecting both the emotional and physical well-being of patients. Here we summarise what is known about the pathophysiology of SCLUs, describe available treatment options and propose a treatment algorithm.
(© 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: