[Blood-brain barrier permeability in healthy rats and rats with experimental C6 glioma after fractionated radiotherapy of the brain].

Autor:	Yusubalieva GM; V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology., Levinskiy AB; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology., Zorkina YA; V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology., Baklaushev VP; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology., Goryaynov SA; Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences., Pavlova GV; Institute of Gene Biology, Russian Academy of Sciences., Mel'nikov PA; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology., Gorlachev GE; V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology; Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences; Institute of Gene Biology, Russian Academy of Sciences., Golanov AV; V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology; Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences; Institute of Gene Biology, Russian Academy of Sciences., Potapov AA; Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences., Chekhonin VP; V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology.
Jazyk:	English; Russian
Zdroj:	Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 2015; Vol. 79 (3), pp. 15-26.
DOI:	10.17116/neiro201579315-26
Abstrakt:	Objective: To evaluate the effect of fractionated radiotherapy on permeability of the blood-brain barrier in healthy rats and rats with C6 glioma in vivo. Material and Methods: An increase in BBB permeability in C6 glioma was assessed by dynamic MRI monitoring (glioma size before and after radiation therapy in combination with immunotherapy, n=30) and confocal microscopy (fluorescence imaging of tumor invasion boundaries in a dose-dependent experiment for the amount of injected antibodies). In healthy rats, BBB permeability to macromolecular substances (MMS) was assessed by ELISA (n=23, 192 plasma samples) and confocal microscopy (n=7). Results: It was shown that BBB permeability to biological macromolecules in blood-brain and brain-blood directions was increased after fractionated radiotherapy. Conclusion: Drug delivery to the brain can be improved using therapeutic doses of radiation treatment that affects the BBB and minimizes the risk of serious side effects that are often associated with the drug dose.
Databáze:	MEDLINE
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